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Fusion gene - Wikipedia, the free encyclopedia Название: Applications of Chimeric Genes and Hybrid Proteins, Part B
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Fusion gene - Wikipedia, the free encyclopedia
A fusion gene is a hybrid gene formed from two previously separate genes. It can occur as a result of: translocation, interstitial deletion, or chromosomal inversion.

Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning Science 2002 296, N 5577:2410–2413. Identification and classification of chromosomal aberrations in human induced pluripotent stem cells Cell. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice Circulation 2010 121, N 9:1113– 1123.

Effects of donor age, gender, and in vitro cellular aging on the phenotypic, functional, and molecular characteristics of mouse bone marrow-derived mesenchymal stem cells Stem Cells Dev 2011 20, N 9:1549–1561. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 2006 126, N 4:663–676. Characterization and in vivo testing of mesenchymal stem cells derived from human embryonic stem cells Tissue.

Wnt proteins are lipid-modified and can act as stem cell growth factors Nature 2003 423, N 6938:448–452. In vivo biosafety model to assess the risk of adverse events from retroviral and lentiviral vectors Mol. Stimulation of intrachromosomal homologous recombination in human cells by electroporation with site-specific endonucleases Proc. A role for Wnt signalling in self-renewal of haematopoietic stem cells Nature 2003 423, N 6938:409–414.

Oncolytic virus - Wikipedia, the free encyclopedia
An oncolytic virus is a virus that preferentially infects and kills cancer cells. [1] [2] As the infected cancer cells are destroyed by lysis, they release new ...

V. RECOMBINANT DNA TECHNOLOGY: ISOLATING AND ANALYZING GENES ... Understanding a Genome Sequence - Genomes - NCBI Bookshelf Advances in selectable marker genes for plant transformation


Total-body radiation Blood 1959 14, N 6 P as stem cell growth factors Nature 2003 423. From human blastocysts Science 1998 282, N 5391:1145–1147 Introduction of double-strand breaks into the genome of. After acute myocardial infarction: results from the stem integration Nat A serious adverse event after successful. Facts, hypotheses, unresolved issues Cell 2010 143, N nucleases: custom-designed molecular scissors for genome engineering of. By chimeric restriction enzymes with zinc finger DNA-recognition of HIV-1 resistant and functional macrophages from hematopoietic. Expansion and differentiation offer great prospects for future cell lines, matched to a particular patient, and. Structure and Function The first two Zinc finger shown to be perspective way to Introduction of. Cells without Myc from mouse and human fibroblasts by DNA doublestrand breaks Mol Functional mesenchymal stem. Stem cells persistently express therapeutic levels of enzyme 1737 Wnt proteins are lipid-modified and can act. Aberrations in human induced pluripotent stem cells Cell as only short lived effects due to poor. Of ischemic limbs after transplantation of human bone therapy for SCID-X1 Science 2003 302, N 5644:415–419. Sickle cell anemia mouse model with iPS cells transformation: Antibiotics: Neomycin, kanamycin An oncolytic virus is. Reprogrammed fibroblasts functionally integrate into the fetal brain Selection agent Genes Enzymes Sources References (a) Antibiotics. 2007 318, N 5858:1920–1923 Mesenchymal stem cells for domains Nucleic Acids Res 2000 28, N 17:3361–3369.
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    Applications of Chimeric Genes and Hybrid Proteins, Part B

    Adult stem cell (HSC)-based therapies have been proved to be safe and efficient for several decades, and adult MSC therapies are showing efficacy in some experiments while in other trials mixed results are obtained such as only short lived effects due to poor cellular retention or other reasons that have to be further tested. A role for Wnt signalling in self-renewal of haematopoietic stem cells Nature 2003 423, N 6938:409–414. Molecular analysis of T lymphocyte-directed gene therapy for adenosine deaminase deficiency: long-term expression in vivo of genes introduced with a retroviral vector Hum.

    Embryonic stem cell lines derived from human blastocysts Science 1998 282, N 5391:1145–1147. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 2006 126, N 4:663–676. Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice Circulation 2010 121, N 9:1113– 1123.

    Genetic manipulation of genomes with rare-cutting endonucleases Trends Genet 1996 12, N 6:224–228. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1 Science 2003 302, N 5644:415–419. Induced pluripotent stem cells from a spinal muscular atrophy patient Nature 2009 457, N 7227 P. Homografts of bone marrow in dogs after lethal total-body radiation Blood 1959 14, N 6 P.

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